7^th Annual Congress on Emergency Nursing & Case Reports April 17-18, 2023 Paris, France

Biography:

Dr.Azad A. Haleem Almezori is an assistant professor of pediatric and pediatric Endocrinologist M.B.Ch.B,DCH,FIBMS,MRCPCH, Iran
 

Abstract:

Case 1- A three-day-old boy with hyperglycemia:
Presentation: This boy was born at 32 weeks of gestation with a birth weight of 1.4 kg. He was in the neonatal intensive care unit on intravenous fluids. Blood sugar was high on routine monitoring (220 mg/dL, 12.2 mmol/L).Plan: Hyperglycemia in the neonatal period is usually due to high dextrose infusion. Neonatal diabetes should be considered only with persistent insulin-requiring hyperglycemia. Details regarding dextrose infusion rate, infection, and vasopressors should be obtained. Assessment: The child had no dehydration. He was on high dextrose infusion (9 mg/kg/minute). Sugar levels normalized after a reduction in dextrose infusion. Diagnosis: Transient hyperglycemia due to high dextrose infusion. Messages

Case 2- A 14-day-old girl with respiratory distress and hyperglycemia:
Presentation: This girl was admitted to the intensive care unit with respiratory distress. She had high blood glucose levels (270 mg/dL, 15 mmol/L).
Plan: An important consideration in a neonate with hyperglycemia includes the effect of stress and steroids.
Assessment: She girl was on steroids and beta-agonists. Glucose levels normalized with a decrease in steroid dose.
Diagnosis: Steroid-induced transient diabetes

Case 3- A 15-day-old girl with hyperglycemia and normal HbA1c:
Presentation: This girl presented with failure to thrive and dehydration. She had high blood glucose (320 mg/dL, 18.2 mmol/L) with normal HbA1C (5.6%).
Plan: High blood glucose, dehydration, and failure to thrive suggest neonatal diabetes; HbA1C may be falsely low in the period due to high fetal hemoglobin. Insulin should be considered in view of the clinical presentation.

Case 4- A five-day-old girl with diabetes and omphalocele:
Presentation: This girl presented with failure to thrive (current weight of 1600 qm as against a birth weight of 1800 qm) and dehydration. Investigations showed high blood glucose (425 mg/dL, 23.4 mmol/L) with no ketosis.
Plan: Early-onset hyperglycemia, low birth weight, and no ketosis suggest transient neonatal diabetes. Careful examination for pointers of TNDM (omphalocele and ear creases) should be done. Assessment The girl had omphalocele and ear creases suggesting TNDM1 due to a DMR defect.
Plan: Hypoglycemia after resolution of transient diabetes suggests increased beta-cell activity due to removal of the suppressive effect of ZAC 1 and HYMA1 genes. She should be started on diazoxide.

Biography:

Rabeya Akter Moni has completed his PhD at the age of 25 years from Andhra University and postdoctoral studies from Stanford University School of Medicine. A premier Bio-Soft service organization. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

Encyclopedia of Bioanalytical Methods for Bioavailability and Bioequivalence Studies of Pharmaceuticals (E-BABE): It is a unique encyclopedia involving bioanalytical methods for bioavailability and bioequivalence (BA/BE) studies of pharmaceuticals for suitable method selection with thousands of combinations and searches against these methods. Most scrutinized literature was collected from different sources including PubMed. This database has been curetted using published methods for all most all pharmaceuticals. Required information for regular method development/validation such as IUPAC name, structure, solubility, chromatographic conditions, instrumentation information like HPLC, LCMS detection parameters, sample preparations, recovery details, limit of detection and limit of quantification, Tmax, Cmax etc., for routine application in BA/BE studies of pharmaceuticals was incorporated including official pharmacopeias information such as European Pharmacopeia, Japan Pharmacopeia and US Pharmacopeia. Database includes drug based bioanalytical methods covering most required fields and external database links of important drug portals such as drug bank, Rxlist, MEDLINE plus, KEGG Drug ID, KEGG Compound ID, Merck manual, PubChem compound ID, PubChem substance ID and USFDA. Searching/querying the database is through drug name, chemical formula or structural search by smiles format. Keen selections of bioanalytical methods for pharmaceutical analysis or regular quality control are also possible with E-BABE. E-BABE was built understanding the needs of pharmaceutical industry and laboratories including CROs working on BA/BE studies. Presently it has nearly of 5,000 methods and it will be updated regularly.

Biography:

Ahmed El Mohamady Mahfouz is affiliated to Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Abstract:

Aim: To assess the role serum thrombomodulin in the diagnosis and prediction of mortality in pediatric septic cases.
Methods: This a prospective cohort study carried out at the Pediatric Intensive Care Unit (PICU) of Menoufia University Hospital. We included 70 critically ill patients admitted to PICU and 25 apparently healthy controls from October 2018 to September 2019. Clinical examination was performed including calculation of the Pediatric Risk of Mortality and Pediatric Index of Mortality II. Serum Thrombomodulin was performed for patients at admission and for the controls. Patients were followed up for 30 days.
Results: Serum Thrombomodulin level was significantly higher among the total patient cohort and those with systemic inflammatory response syndrome, sepsis and severe sepsis than among the controls (p<0.001), Furthermore, Serum Thrombomodulin was significantly elevated in non survivors compared with survivors (p=0. 005). Receiver-operating characteristic curve analysis exhibited an Area Under the Curve (AUC) of 0.915 for Thrombomodulin for prediction of sepsis, whereas C-reactive protein had AUC of 0.789. Regarding the prognosis, PIIINP had AUC of 0.711 for prediction of mortality, whereas the AUC for Pediatric Risk of Mortality and Pediatric Index of Mortality 2 were 0.918, 0.960 respectively.